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Exempt media consists of highly stable formulations with a proven track record of minimal failure rates. Laboratories do not need to perform full user QC (such as inoculation with control organisms) on these media if they receive documentation from the manufacturer proving the lot passed QC. Examples of commonly exempt media include: Sheep Blood Agar (SBA) MacConkey Agar (MAC)
M22-A3 strongly recommends using at least 40 patient samples (range covering the reportable interval) against a reference method (e.g., LC-MS/MS vs. immunoassay). For interferences, the guideline specifies testing: clsi m22a3 pdf
The core premise of M22-A3 is that retesting commercially prepared media is often unnecessary if the media has a proven track record of high reliability. By analyzing failure rates from surveys conducted by the College of American Pathologists (CAP), the CLSI identified specific media types that consistently perform well.
You can purchase or access the document through the CLSI official site or through authorized standard sellers like ANSI or Accuris . If you can tell me: A common search query is for a
The document provides clear protocols for maintaining QC organisms, incubation conditions, and documenting media receipt. Key Sections of the M22-A3 Standard
Focus on visual inspection and documentation of media upon receipt rather than full organism-based retesting for "exempt" media. Laboratories do not need to perform full user
Perform comprehensive QC testing on every batch/lot of media.
Use the standard to establish rigorous QC protocols for every lot.
: Using specific "ATCC" (American Type Culture Collection) control strains to confirm the media supports expected growth.
Published by the , this document provides specific protocols for the quality control (QC) of commercially manufactured microbiological culture media. Its primary goal is to ensure that the media used in laboratories is capable of supporting the growth of target pathogens while remaining sterile and chemically stable. The "Exempt" vs. "Non-Exempt" Classification